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Dengue, zika and chikungunya are globally important arboviruses. In the absence of a vaccine, health entities focus mainly on  vector control using insecticides, Growth Regulatory Insecticides (IRC), including Novaluron, have proven to be effective in vector control. The objective was to determine the optimal application dose of Novaluron 0.2G on the emergence of Aedes aegypti in an urban area endemic for dengue, Carepa, in the department of Antioquia, Colombia. Twenty-one dwellings were randomly selected, where three 250-L tanks were located, two corresponded to treatments and one to control, evaluating three concentrations (treatments), ramdomly selected for each dwelling. The study was carried out for 18 weeks: seven weeks of pre-treatment, one week of product application and ten  weeks of post-treatment. For this, the pupae of A. aegypti were collected, allowing the emergence of  adult mosquito under controlled conditions, in order to estimate the weekly inhibition of the emergence. The results indicated that a reduction in the emergence of A. aegypti of close to 100% was achievedwith the highest concentration evaluated (0.584 mg/L). For the other concentrations (0.292 and 0.146 mg/L), the percent  inhibition of emergence for week two was 79% and 45%, respectively.

Quimbayo F., M., Amaya, J. D., & Rúa-Uribe, G. L. (2022). Evaluation of Novaluron 0.2 G against Aedes (Stegomyia) aegypti (Diptera: Culicidae) in an urban area in Antioquia, Colombia. Revista Colombiana De Entomología, 48(1). https://doi.org/10.25100/socolen.v48i1.11093

ANIPSITAKIS, G. P.; DIONYSIOU, D. D. 2003. Degradation of organic contaminants in water with sulfate radicals generated by the conjunction of Peroxymonosulfate with Cobalt. Environmental Science & Technology 37 (20): 4790-4797. http://dx.doi.org/10.1021/es0263792

ARDILA-ROLDÁN, S.; SANTACOLOMA, L.; BROCHERO, H. 2013. Estado de la susceptibilidad a insecticidas de uso en salud pública en poblaciones naturales de Aedes aegypti (Diptera: Culicidae) del departamento de Casanare, Colombia. Biomédica 33 (3): 446-458. http://dx.doi.org/10.7705/biomedica.v33i3.1534

ARREDONDO-JIMÉNEZ, J. I.; VALDEZ-DELGADO, K. M. 2006. Effect of Novaluron (Rimon ® 10 EC) on the mosquitoes Anopheles albimanus, Anopheles pseudopunctipennis, Aedes aegypti, Aedes albopictus and Culex quinquefasciatus from Chiapas, Mexico. Medical and Veterinary Entomology 20 (4): 377-387. https://pubmed.ncbi.nlm.nih.gov/17199749/

BANG, Y. H.; PANT, C. P. 1972. A field trial of Abate larvicide for the control of Aedes aegypti in Bangkok, Thailand. Bulletin of the World Health Organization 46 (3): 416-425. https://apps.who.int/iris/handle/10665/263436

BHATIA, M. S.; GAUTAM, P.; JHANJEE, ANURAG. 2015. Psychiatric Morbidity in patients with Chikungunya fever:

First report from India. Journal of Clinical and Diagnostic Research. 9 (10): VC01-VC03.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625314/

CASTRILLÓN, J. C.; CASTAÑO, J. C.; URCUQUI, S. 2015. Dengue en Colombia: diez años de evolución. Revista

Chilena de Infectología 32 (2): 142-149. http://dx.doi.org/10.4067/s0716-10182015000300002

CONDE, M.; ORJUELA, L.; CASTELLANOS, C.; HERRERA-VARELA, M.; LICASTRO, S.; QUIÑONES, M. 2015. Evaluación de la sensibilidad a insecticidas en poblaciones de Aedes aegypti (Diptera: Culicidae) del departamento de Caldas, Colombia, en 2007 y 2011. Biomédica 35 (1): 43-52. http://dx.doi.org/10.7705/biomedica.v35i1.2367

CUEVAS, E. L, TONG, V. T.; ROZO, N.; VALENCIA, D.; PACHECO, O.; GILBOA, S. M.; MERCADO, M.; RENQUIST, C. M., GONZÁLEZ, M.; RICO TURCA, A. M.; CALLES, D. L.; AYALA, M,; MORGAN, P.; TOLOSO PEREZ, E. N.; QUIJADA BONILLA, H.; CACERES GOMEZ, R.; ESTUPIÑAN, A. C.; GUNTURIZ, M. L.; MEANY-DELMAN, D.; JAMIESON, D. J.; HONEIN, M. A.; OSPINA MARTÍNEZ, M. L. 2016. Preliminary report of

microcephaly potentially associated with Zika virus infection during pregnancy- Colombia, January–November 2016.

MMWR Morbidity and Mortality Weekly Report 65 (49): 1409-1413. http://dx.doi.org/10.15585/mmwr.mm6549e1 ELIA-AMIRA, N. M. R.; CHEN, C. D.; LOW, V. L.; LAU, K. W.; HAZIQAH-RASHID, A.; AMELIA-YAP, Z. H.; LEE,

H. L.; SOFIAN-AZIRUN, M.2021. Statewide efficacy assessment of insect growth regulators against Aedes

albopictus (Diptera: Culicidae) in Sabah, Malaysia: An alternative control strategy? Journal of Medical Entomology 20

(10): 1-7. http://dx.doi.org/10.1093/jme/tjab146

FARNESI, L. C.; BRITO, J. M.; LINSS, J. G.; PELAJO-MACHADO, M.; VALLE, D.; REZENDE, G. L. 2012. Physiological and morphological aspects of Aedes aegypti developing larvae: effects of the chitin synthesis inhibitor Novaluron. PLoS One 7 (1): e30363. https://doi.org/10.1371/journal.pone.0030363

FIAZ, M.; MARTÍNEZ, L. C.; PLATA-RUEDA, A.; COSSOLIN, J. F. S.; SERRA, R. S.; MARTINS, G. F.; SERRÃO, J. E.2021. Behavioral and ultrastructural effects of novaluron on Aedes aegypti larvae. Infection, Genetics and Evolution 93: 104974. http://dx.doi.org/10.1016/j.meegid.2021.104974

FONSECA, E. O. L.; MACORIS, M. L. D. G.; SANTOS, R. F. D.; MORATO, D. G.; ISABEL, M. D. S. S.; CERQUEIRA, N. A.; MONTE-ALEGRE, A. F. 2019. Experimental study on the action of larvicides in Aedes aegypti populations collected in the Brazilian municipality of Itabuna, Bahia, under simulated field conditions. Epidemiologia e Serviços de Saúde 28 (1): e2017316. https://doi.org/10.5123/S1679-49742019000100004

GUNATHILAKA, N.; RANATHUNGA, T.; HETTIARACHCHI, D.; UDAYANGA, L.; ABEYEWICKREME, W. 2020. Field-based evaluation of Novaluron EC10 insect growth regulator, a chitin synthesis inhibitor against dengue vector breeding in leaf axils of pineapple plantations in Gampaha District, Sri Lanka. Parasites & Vectors 13 (228). http://dx.doi.org/10.1186/s13071-020-04109-y

IBM Corp. 2017. IBM SPSS Statistics for Windows, Version 25.0. Armonk, NY: IBM Corp.

IKAWATI, B.; SUNARYO.; WAHYUDI, B. F. 2017. Aedes aegypti resistance to Temephos in Central Java, Indonesia. Advanced Science Letters 23 (4): 3544-3546. http://dx.doi.org/10.1166/asl.2017.9163

INSTITUTO NACIONAL DE SALUD. 2017. Protocolo de vigilancia en salud pública. Dengue. Disponible en: https://www.ins.gov.co/Noticias/Dengue/7.%20Dengue%20PROTOCOLO.pdf . Fecha revisión: 5 de octubre 2020.

INSTITUTO NACIONAL DE SALUD. 2019. Boletín epidemiológico semanal. Semana Epidemiológica 52 2019. Disponible en: https://www.ins.gov.co/buscador-eventos/BoletinEpidemiologico/2019_Boletin_epidemiologico_semana_52.pdf . [Fecha revisión: 1 de julio 2020].

JAMBULINGAM, P.; SADANANDANE, C.; NITHIYANANTHAN, N.; SUBRAMANIAN, S., ZAIM, M. 2009. Efficacy of Novaluron against Culex quinquefasciatus in small- and medium-scale trials, India. Journal of the American Mosquito Control Association 25 (3): 315-322. http://dx.doi.org/10.2987/08-5806.1

KOURI, G. 2006. El dengue, un problema creciente de salud en las Américas. Revista Cubana de Salud Pública 19 (3): 145-143. http://dx.doi.org/10.1590/s1020-49892006000300001

LAU, K. W.; CHEN, C. D.; LEE, H. L.; NORMA-RASHID, Y.; SOFIAN-AZIRUN, M. 2015. Evaluation of insect growth regulators against field-collected Aedes aegypti and Aedes albopictus (Diptera: Culicidae) from Malaysia. Journal of Medical Entomology 52 (2): 199-206. http://dx.doi.org/10.1093/jme/tju019

LAU, K. W.; CHEN, C. D.; LEE, H. L.; LOW, V. L.; SOFIAN-AZIRUN, M. 2018. Bioefficacy of insect growth regulators against Aedes albopictus (Diptera: Culicidea) from Sarawak, Malaysia: A statewide survey. Journal of Economic Entomology 111 (3): 1388-1394. http://dx.doi.org/10.1093/jee/toy071

LLINÁS, G. A.; SECCACINI, E.; GARDENAL, C. N.; LICASTRO, S. 2010. Current resistance status to temephos in Aedes aegypti from different regions of Argentina. Memórias do Instituto Oswaldo Cruz 105 (1): 113-116. http://dx.doi.org/10.1590/s0074-02762010000100019

MARINA, C. F.; BOND, J. G.; MUÑOZ, J.; VALLE, J.; QUIROZ-MARTÍNEZ, H.; TORRES-MONZÓN, J. A.; WILLIAMS, T. 2020. Comparison of Novaluron, pyriproxyfen, spinosad and temephos as larvicides against Aedes aegypti in Chiapas, Mexico. Salud Pública de México 62 (4): 424-431. http://dx.doi.org/10.21149/10168

MINISTERIO DE LA PROTECCIÓN SOCIAL;INSTITUTO NACIONAL DE SALUD; ORGANIZACIÓN PANAMERICANA DE LA SALUD (MPS/INS/OPS). 2008. Disponible en: https://www.paho.org/col/index.php?option=com_docman&view=download&category_slug=publicaciones-ops-oms-colombia&alias=432-guia-dengue-210310&Itemid=688. [Fecha revisión: 16 de julio 2020].

MULLA, M. S.; DARWAZEH, H. A.; LEE NORLAND, R. 1974. Insect growth regulators: Evaluation procedures and activity against mosquitoes1. Journal of Economic Entomology 67 (3): 329-332. http://dx.doi.org/10.1093/jee/67.3.329

NWANKWO, E.; OKONKWO, N.; OZUMBA, N.; OKAFOR, E. 2011. Comparative studies on the larvicidal action of Novaluron (Mosquiron® 100EC) and Moringa oleifera (LAM) seed oil against Aedes aegypti (Diptera: Culicidae) larvae. African Research Review 5 (1): 424-437. http://dx.doi.org/10.4314/afrrev.v5i1.64539

OCAMPO, C. B.; SALAZAR-TERREROS, M. J.; MINA, N. J.; MCALLISTER, J.; BROGDON, W. 2011. Insecticide resistance status of Aedes aegypti in 10 localities in Colombia. Acta Tropica 118 (1): 37-44. http://dx.doi.org/10.1016/j.actatropica.2011.01.007

ORGANIZACIÓN MUNDIAL DE LA SALUD (OMS). 2017. Respuesta mundial para el control de vectores 2017- 2030. Documento de contexto para informar las deliberaciones de la Asamblea Mundial de la Salud en su 70.ª reunión. Disponible en: https://www.who.int/malaria/areas/vector_control/Draft-WHO-GVCR-2017-2030-esp.pdf?ua=1 . [Fecha revisión: 15 de julio del 2020].

ORGANIZACIÓN PANAMERICANA DE LA SALUD (OPS). 2020. Actualización epidemiológica dengue. Disponible en: https://www.paho.org/sites/default/files/2020-02/2020-feb-7-phe-actualizacion-epi-dengue.pdf. [Fecha revisión: 1 de julio del 2020].

PADILLA, J. C.; LIZARAZO, F. E.; MURILLO, O. L; MENDIGAÑA, F. A; PACHÓN, E.; VERA, M. J. 2017. Epidemiología de las principales enfermedades transmitidas por vectores en Colombia, 1990-2016. Biomédica 37 (Sup2): 27-40. https://doi.org/10.7705/biomedica.v37i0.3769

PADILLA, J. C.; ROJAS, D. P.; SAENZ-GOMEZ, R. 2012. Dengue en Colombia: epidemiologia de la reemergencia a la hiperendemia. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/INEC/INV/Dengue%20en%20Colombia.pdf [Fecha revisión: 15 de julio 2020].

PENER, M. P.; DHADIALLA, T. S. 2012. An overview of insect growth disruptors; Applied aspects. Advances in Insect Physiology 1-162. http://dx.doi.org/10.1016/b978-0-12-391500-9.00001-2

QUIMBAYO, F. M.; PÉREZ-PÉREZ, J.; RODRÍGUEZ-GAVIRIA, P. A.; AMAYA, J. D.; RÚA-URIBE, G. L. 2019. Evaluación de la eficacia de Novaluron 0,2 % GR para el control de Aedes (Stegomyia) aegypti (Diptera). Revista Colombiana de Entomología 45 (1): e7812. http://dx.doi.org/10.25100/socolen.v45i0.7812

RINCÓN-SILVA, N. G.; RINCÓN SILVA, J. D. 2016. Impacto general de las fiebres del Zika y Chikungunya en Colombia y América del Sur: Análisis general de los virus y su importancia. Biociencias 11 (2): 77í95. http://dx.doi.org/10.18041/2390-0512/bioc..2.2566

SAEUNG, M.; NGOEN-KLAN, R.; THANISPONG, K.; MUENWORN, V.; BANGS, M. J.; CHAREONVIRIYAPHAP, T. 2020. Susceptibility of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) to Temephos in Thailand and surrounding countries. Journal of Medical Entomology 57 (4): 1207-1220. http://dx.doi.org/10.1093/jme/tjaa035

SWALE, D. R.; LI, Z.; KRAFT, J. Z.; HEALY, K.; LIU, M.; DAVID, C. M.;LIU, Z.; FOIL, L.D. 2018. Development of an autodissemination strategy for the deployment of novel control agents targeting the common malaria mosquito, Anopheles quadrimaculatus Say (Diptera: Culicidae). PLOS Neglected Tropical Diseases 12 (4): e0006259. http://dx.doi.org/10.1371/journal.pntd.0006259

SECRETARIA DE SALUD MUNICIPAL DE CAREPA ANTIOQUIA. 2016. Plan territorial de salud del municipio de Carepa. Fecha de consulta. 5 de octubre 2020. Disponible en: https://www.carepa-antioquia.gov.co/NuestraAlcaldia/EvaluacionAcuerdosGestion/PLAN%20DE%20DESARROLO%20CON%20ANEXOS.pdf

SHEPARD, D. S.; UNDURRAGA, E. A.; HALASA, Y. A.; STANAWAY, J. D. 2016. The global economic burden of dengue: a systematic analysis. The Lancet Infectious Diseases 16 (8): 935-941. http://dx.doi.org/10.1016/s1473-3099(16)00146-8

WITHANAGE, G. P.; VISWAKULA, S. D.; GUNAWARDENE, Y. S.; HAPUGODA, M. D. 2020. Use of Novaluron-based autocidal gravid ovitraps to control Aedes Dengue vector mosquitoes in the District of Gampaha, Sri Lanka. BioMed Research International 1-9. https://doi.org/10.1155/2020/9567019

WORLD HEALT ORGANIZATION (WHO). 2009. Dengue: guidelines for diagnosis, treatment, prevention and control. Geneva: World Health Organization. Disponible en: https://apps.who.int/iris/handle/10665/44188 [Fecha revisión: 15 de junio 2020]

WORLD HEALTH ORGANIZATION (WHO). 2012. Global strategy for dengue prevention and control 2012-2020. Disponible en: https://apps.who.int/iris/bitstream/handle/10665/75303/9789241504034_eng.pdf [Fecha revisión: 30 de junio 2020].

WORLD HEALTH ORGANIZATION. DIVISION OF VECTOR BIOLOGY AND CONTROL. 1981. Instructions for determining the susceptibility or resistance of mosquito larvae to insecticides. Disponible en: https://apps.who.int/iris/handle/10665/69615 . [Fecha revisión: 11 de julio 2020].

Received 2021-03-23
Accepted 2022-01-07
Published 2022-01-28