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10.25100/socolen.v39i2.8240
Submitted: 05-07-2019
Published: 15-07-2013

Effect of carbonic anhydrase inhibitors on Anopheles albimanus larvae (Diptera: Culicidae)

Keywords: Larvicide, Mosquito Control, Vectors, Malaria

How to Cite

1.
Rocha O. L, Torres G. C, Corena-McLeod M, Vélez B. ID, Robledo R. SM. Effect of carbonic anhydrase inhibitors on Anopheles albimanus larvae (Diptera: Culicidae). Rev. Colomb. Entomol. [Internet]. 2013 Jul. 15 [cited 2026 Oct. 25];39(2):226-8. Available from: https://revistacolombianaentomologia.univalle.edu.co/index.php/SOCOLEN/article/view/8240
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Abstract

Carbonic anhydrase (CA) catalyzes the reversible conversion of CO2 to bicarbonate and participates in mechanisms of alkalinization in the intestine of mosquitoes. The toxicity of four CA inhibitors (CAI ): acetazolamide (AZ M), methazolamide (MZM), ethoxolamide (ETX) and dorzolamide (DZA ) were evaluated in larvae of Anopheles albimanus by monitoring mortality 24, 48 and 72 hours post application, at a concentration of 50 ug/ml diluted in dimethyl sulfoxide previously. All IA C reduced the population of larvae in variable proportions. ETX showed the highest toxicity, achieving more than 80% mortality after 24 hours and 98% after 72 hours of application. The CAI , AZ M, MZM and DZA showed less toxicity (<50% mortality). Our results indicate that the CAI , including ETX in particular, is a worthy candidate as an alternative for the control of An. albimanus, which is considered a primary vector of malaria in Colombia.

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How to Cite

1.
Rocha O. L, Torres G. C, Corena-McLeod M, Vélez B. ID, Robledo R. SM. Effect of carbonic anhydrase inhibitors on Anopheles albimanus larvae (Diptera: Culicidae). Rev. Colomb. Entomol. [Internet]. 2013 Jul. 15 [cited 2026 Oct. 25];39(2):226-8. Available from: https://revistacolombianaentomologia.univalle.edu.co/index.php/SOCOLEN/article/view/8240
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Copyright (c) 2013 Leonardo Rocha O., Carolina Torres G., María Corena-McLeod, Iván D. Vélez B., Sara M. Robledo R.